Postdoctoral positions at University of Michigan Medical School, Ann Arbor
NIH grant-funded postdoctoral positions are available immediately in the Yin/Tong lab in the Department of Molecular & Integrative Physiology at the University of Michigan Medical School to investigate the molecular and cellular mechanisms involved in the onset and development of diet-induced non-alcoholic steatohepatitis (NASH). Our lab utilizes a variety of state-of-the-art approaches to assess the changes of histology, transcripts, metabolites, and proteins/protein posttranslational modifications in the livers of genetically modified mouse models with diet-induced NASH. We also routinely isolate primary cells for metabolic assays with radiolabeled substrates or co-culture system and perform genetic analysis of human NASH liver samples.
Interested candidates with an inquisitive mind and a strong motivation for independent research are encouraged to apply. Candidates should have Ph.D. and/or M.D. degrees and candidates with research experience in one or more of the above-mentioned areas are preferred. The Yin/Tong lab is located at the newly established Elizabeth Weiser Caswell Diabetes Center on the North campus of Research Complex at the University of Michigan. The Caswell Diabetes Center provides a highly collaborative and collegial environment with diverse research labs in studying diabetes and metabolic abnormalities.
Postdocs will by supported by a stipend of $53,760 in the first year, which is stipulated by the NIH Postdoctoral Stipend guideline and will be increased annually based on experience and productivity. Ann Arbor is a vibrant college town with easy access to urban amenities, cultural events, and outdoor activities for work-life balance. The University of Michigan is committed to diversity, equity, and inclusion and has a very strong track record in the training and mentoring of postdoctoral fellows. Please send inquiries and C.V.s to Dr. Lei Yin at leiyin@umich.edu or Dr. Xin Tong at xintong@umich.edu.
Relevant recent publications:
Zhang D, Tong X, Gupta N, Omary B, Rui L, Lin JD, Yin L. The lipogenic factor ChREBP mediates fructose-induced metabolic adaptions to prevent hepatotoxicity. Journal Clinical Investigation, 2017 127(7):2855-2867
Tong X, Zhang D, Shabandri O, Charney N, Yang MC, Stamper K, Jin E, Yin L. High fructose diet promotes liver De Novo lipogenesis pathway by stabilizing ChREBP via DDB1-mediated CRY1 degradation. Metabolism, 2020 107: 154222
Zhang D, Wang S, Ospina E, Shanbandrd O, Lank D, Akakpo J, Zhao Z, Yang M, Wu J, Jaeschke H, Saha P, Tong X and Yin L.: Acetaminophen-induced hepatoxicity mainly via activating the ChREBPa-FGF21 axis in mice. Hepatology Communication 2021 5(6): 992-1008
Yang M, Zhang D, Zhao Z, Sit J, Saint-Sume M, Shabandri O, Zhang K, Yin L, Tong X.: Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet induced ER stress. FASEB J 2020 34(10): 13533-13547
Zhang D, Tong X, Nelson BB, Jin E, Sit J, Charney N, Yang M, Omary MB, Yin L.: The hepatic BMAL1 /AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARα pathway Hepatology 2018 68(3): 883-896
Tong X, Zhang D, Charney N, Jin E, VanDommelen K, Stamper K, Gupta N, Saldate J, Yin L.: DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver Diabetes 2017 66(10): 2571-258
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